TP-3654 (PIM Inhibitor)
TP-3654 is a second-generation, selective PIM kinase inhibitor.1
PIM as a potential target in cancer and inflammatory disorders
PIM kinases are frequently overexpressed in various hematologic and solid tumors, allowing cancer cells to evade apoptosis and promoting tumor growth.2 In inflammatory disorders, PIM-1 kinase has been shown to mediate interleukin-22 signaling in cell-based and animal models.
PIM=proviral integration site for Moloney murine leukemia virus.
TP-3654 is an investigational agent and is not approved by the US FDA or any other regulatory authorities.
- 1. Foulks JM, Carpenter KJ, Luo B, et al. A small-molecule inhibitor of PIM kinases as a potential treatment for urothelial carcinomas. Neoplasia. 2014;16(5):403-412. 2. Mondello P, Cuzzocrea S, and Mian M. Pim kinases in hematological malignancies: where are we now and where are we going? J Hematol Oncol. 2014;7:95.