Discovery through scientific rigor and commitment to innovation

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Targeted therapy is at the heart of our pipeline

Tolero has a pathway-centric pipeline of investigational agents aimed at targeting abnormalities in cell function in the context of pathway inhibition. Our approach is to develop specific inhibitors of signaling pathways and identify diseases dependent on these pathways.

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Zella 201 Trial

Late-stage investigations of targeted therapy

Zella 201 is a clinical trial of alvocidib in combination with cytarabine and mitoxantrone (ACM), in adult patients with relapsed or refractory acute myeloid leukemia (AML), with a second exploratory arm in adult patients with newly diagnosed high-risk AML.

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Understanding AML blast survival through MCL-1 and CDK9 activity

 In this target-driven era of AML treatment, understanding the distinguishing characteristics of AML subsets is a clinical necessity.